BREAKING: Top Bills RB Sidelined with Painful Injury - Will He Return This Season?"

The Buffalo Bills suffered a significant blow on Monday night as their leading rusher, James Cook, was made inactive for their game against the host New York Jets. Cook was nursing a toe injury that he sustained prior to the game, and despite being listed as questionable on the injury report, the team's medical staff decided it was best to hold him out of the contest.

Cook, who has been a crucial component of the Bills' offense this season, was limited in practice on Saturday, which raised concerns about his availability for the game. However, the team was optimistic that he would be able to suit up and contribute to their efforts against the Jets.

Unfortunately for the Bills, Cook was unable to overcome the discomfort and pain caused by the toe injury, and the team's coaching staff made the decision to sit him out of the game. This is a significant loss for the Bills, as Cook has been one of their most reliable players on offense.

While the extent of Cook's injury is unclear at this time, the team is hopeful that he will be able to return to the field soon. In the meantime, the Bills will have to rely on their other running backs to fill the void left by Cook's absence.

Cook's injury serves as a reminder of the physical toll that football can take on players. The Bills will have to be cautious and make sure that Cook is fully healed before allowing him to return to the field.

The Bills' game against the Jets is crucial in their bid for a playoff spot, and the absence of Cook will undoubtedly make it more challenging for them to secure a win. However, the team remains optimistic about their chances and will look to their other players to step up and fill the void left by Cook's absence.